Modeling the Central Carbon Metabolism of Sulfolobus solfataricus

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Welcome to the SulfoSYS model page!

SulfoSYS is a Systems Biology Consortium with the aim to describe the dynamics as well as temperature and homeostatic behaviors of the central carbon metabolism in the thermoacidophilic organism Sulfolobus solfataricus. This page connects to a Fortran program, which simulates the central C-metabolism of Sulfolobus solfataricus.

This page provides also a link to binaries tested for Mac OS X (Intel), Linux (Ubuntu 9.x), and Windows-XP. The binaries and source code - written in FORTRAN - can be downloaded here. To compile the source code a FORTRAN compiler is required.

To start running the online FORTRAN interface, go to the input parameter and run page (opens in a separate tab/window). Use the pre-selected kinetic parameter values or apply changes to the numerical values. Click then the "Run" button. The generated output page will show you a copy of your input as well as the numerical output data (concentrations as a function of time). Plot outputs for each enzyme with substrates and products are automatically generated and can be viewed at the plot output page (opens in a separate tab/window; to view the plots you have to return to this page). If you have applied changes to rate parameters, please be sure to update the plots after the calculation by using your browser's update button.

The various rate parameters are indicated in green in the scheme below (for getting a better view, click on picture).

last updated: October 31, 2009.